Toxins, Free Full-Text
Por um escritor misterioso
Descrição
L-Amino acid oxidase (LAAO) is an enzyme found in snake venom that has multifaceted effects, including the generation of hydrogen peroxide (H2O2) during oxidative reactions, leading to various biological and pharmacological outcomes such as apoptosis, cytotoxicity, modulation of platelet aggregation, hemorrhage, and neutrophil activation. Human neutrophils respond to LAAO by enhancing chemotaxis, and phagocytosis, and releasing reactive oxygen species (ROS) and pro-inflammatory mediators. Exosomes cellular nanovesicles play vital roles in intercellular communication, including immune responses. This study investigates the impact of Calloselasma rhodostoma snake venom-derived LAAO (Cr-LAAO) on human neutrophil exosome release, including activation patterns, exosome formation, and content. Neutrophils isolated from healthy donors were stimulated with Cr-LAAO (100 μg/mL) for 3 h, followed by exosome isolation and analysis. Results show that Cr-LAAO induces the release of exosomes with distinct protein content compared to the negative control. Proteomic analysis reveals proteins related to the regulation of immune responses and blood coagulation. This study uncovers Cr-LAAO’s ability to activate human neutrophils, leading to exosome release and facilitating intercellular communication, offering insights into potential therapeutic approaches for inflammatory and immunological disorders.
Clean Living: How to Reduce your Toxic Load - Finesse Fitness
Toxins in Hair Dyes and the Safest Alternatives That Work — 3 Little Plums
Declutter Toxins from Your Home and Life with Dr. Jenna Hua — Wannabe Clutter Free
Intrahepatic transplantation of adipose‑derived stem cells attenuates the progression of non‑alcoholic fatty liver disease in rats
The Ultiamte Guide to Toxin-Free Living
Socioenvironmental adversity and adolescent psychotic experiences: Exploring potential mechanisms in a UK longitudinal cohort [Schizophrenia Bulletin, Mar 2023 -- free full-text] : r/psychopathology
Non-Toxic” Proteins of the Botulinum Toxin Complex Exert In-vivo Toxicity
Toxicity Stock Photos, Royalty Free Toxicity Images
Toxin Free - Carolina Total Wellness
de
por adulto (o preço varia de acordo com o tamanho do grupo)
